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The drugs they studied included cocaine and a few others that have some similarities to cocaine in how they affect the brain. They trained the monkeys to give themselves these drugs through injections and observed their behavior. They wanted to see if the drugs had similar effects on the monkeys.
Some of the symptoms that result from cell death include loss of motor control, cognitive deterioration and autonomic nervous system dysfunction. Additionally, neurotoxicity has been found to be a major cause of neurodegenerative diseases such as Alzheimer's disease (AD). [citation needed]
Cocaine- and amphetamine-regulated transcript, also known as CART, is a neuropeptide protein that in humans is encoded by the CARTPT gene. [ 1 ] [ 2 ] CART appears to have roles in reward, feeding, and stress, [ 3 ] and it has the functional properties of an endogenous psychostimulant .
Locomotor activity is a measure of animal behavior which is employed in scientific research. [1] [2]Hyperlocomotion, also known as locomotor hyperactivity, hyperactivity, or increased locomotor activity, is an effect of certain drugs in animals in which locomotor activity (locomotion) is increased. [3]
The neurotransmitter dopamine is a key candidate for explanation of reinforcing actions drugs. [6] [7] It's unclear to which extent NET is involved in the reinforcing actions of cocaine (an SNDRI). [8] Animal studies show evidence that inhibiting the SERT might reduce cocaine intake. [9]
Cocaine is a relatively "balanced" inhibitor, although facilitation of dopaminergic neurotransmission is what has been linked to the reinforcing and addictive effects. In addition, cocaine has some serious limitations in terms of its cardiotoxicity [188] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency ...
San Diego sector Border Patrol agents announced the seizure of more than 80 pounds of cocaine in Temecula. The drugs were stashed inside an SUV's false dashboard, authorities said.
Cocaine addiction results from complex molecular changes in the brain following multiple exposures to cocaine. [16] Dynorphins have been shown to be an important part of this process. Although a single exposure to cocaine does not affect brain dynorphin levels, repeated exposures to the drug increases dynorphin concentrations in the striatum ...