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The drugs they studied included cocaine and a few others that have some similarities to cocaine in how they affect the brain. They trained the monkeys to give themselves these drugs through injections and observed their behavior. They wanted to see if the drugs had similar effects on the monkeys.
Locomotor activity is a measure of animal behavior which is employed in scientific research. [1] [2]Hyperlocomotion, also known as locomotor hyperactivity, hyperactivity, or increased locomotor activity, is an effect of certain drugs in animals in which locomotor activity (locomotion) is increased. [3]
SSRIs are not self-administered either. Hence, it should be borne in mind that these neurotransmitters are unlikely to be involved in the addiction forming properties of cocaine and related stimulants. Nevertheless, they are still behaviorally active and will contribute to the effects that such drugs elicit in their users.
Cocaine- and amphetamine-regulated transcript, also known as CART, is a neuropeptide protein that in humans is encoded by the CARTPT gene. [ 1 ] [ 2 ] CART appears to have roles in reward, feeding, and stress, [ 3 ] and it has the functional properties of an endogenous psychostimulant .
Genetic variation in this region also displays influence susceptibility to use drugs of abuse, including cocaine and alcohol consumption. [44] Nicotinic receptors containing α 6 or β 3 subunits expressed in brain regions, especially in the ventral tegmental area and substantia nigra , are important for drug behaviors due to their role in ...
San Diego sector Border Patrol agents announced the seizure of more than 80 pounds of cocaine in Temecula. The drugs were stashed inside an SUV's false dashboard, authorities said.
Cocaine's mechanism of action in the human brain includes the inhibition of dopamine reuptake, [49] which accounts for cocaine's addictive properties, as dopamine is the critical neurotransmitter for reward. However, cocaine is more active in the dopaminergic neurons of the ventral tegmental area than the substantia nigra.
Like methadone, Suboxone blocks both the effects of heroin withdrawal and an addict’s craving and, if used properly, does it without causing intoxication. Unlike methadone, it can be prescribed by a certified family physician and taken at home, meaning a recovering addict can lead a normal life, without a daily early-morning commute to a clinic.