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Lac repressor (LacI) is a protein that regulates the expression of lactose metabolism genes in bacteria. Learn about its function, structure, kinetics, and allosteric regulation by lactose and allolactose.
The lactose operon (lac operon) is an operon required for the transport and metabolism of lactose in E. coli and many other enteric bacteria.Although glucose is the preferred carbon source for most enteric bacteria, the lac operon allows for the effective digestion of lactose when glucose is not available through the activity of β-galactosidase. [1]
In order to understand and model the design and cellular mechanisms that confers a cell’s function, Elowitz and Leibler created an artificial network consisting of a loop with three transcriptional repressors. This network was designed from scratch to exhibit a stable oscillation that acts like an electrical oscillator system with fixed time ...
In E. coli, the lacZ gene is the structural gene for β-galactosidase; which is present as part of the inducible system lac operon which is activated in the presence of lactose when glucose level is low. β-Galactosidase synthesis stops when glucose levels are sufficient. [2] β-Galactosidase has many homologues based on similar sequences.
A silencer is a DNA sequence that binds repressors, which are proteins that prevent transcription of a gene. Learn about the types, locations, mechanisms and examples of silencers in eukaryotes and prokaryotes.
Galactoside permease is a protein coded by the lacY gene of the lac operon, and is found bound to the membrane of a cell for the purpose of binding galactoside molecules that have been solubilized. The protein is part of a system whose main function is to catalyze the accumulation and transport of lactose and other beta-galactosides across the ...
The T7 expression system is a method to clone recombinant DNA using E. coli and T7 RNA polymerase. It is widely used for expressing recombinant proteins and mRNA vaccines, and was developed at Brookhaven National Laboratory.
A repressor is a protein that inhibits gene expression by binding to an operator or mRNA. Learn how repressors work, how they are regulated by inducers or co-repressors, and see examples from lac, met and arabinose operons.