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Invasive candidiasis is an infection (candidiasis) that can be caused by various species of Candida yeast. Unlike Candida infections of the mouth and throat (oral candidiasis) or vagina (Candidal vulvovaginitis), invasive candidiasis is a serious, progressive, and potentially fatal infection that can affect the blood (), heart, brain, eyes, bones, and other parts of the body.
Candidiasis is a fungal infection due to any species of the genus Candida (a yeast). [4] When it affects the mouth, in some countries it is commonly called thrush. [3] Signs and symptoms include white patches on the tongue or other areas of the mouth and throat. [3]
Fungal meningitis may be caused by the following (and also other) types of fungi: [1] [2] [3] Candida - C. albicans is the most common Candida species that causes infections of the central nervous system.
Infections of the central nervous system (CNS) consist of infections primarily of the brain and spinal cord. They include mostly viral infections, less commonly bacterial infections, fungal infections, prion diseases and protozoan infections. Neonatal meningitis is a particular classification by age.
The mechanism the human immune system has is normally to fight an infection (like Candida). Initially, Th17 cells are made by the immune system, which in turn produces interleukin-17 (IL-17). This induces inflammation and white blood cells confront infection. [9] Chronic mucocutaneous candidiasis mutations affect IL-17 by inhibiting its pathway.
Candida auris has attracted increased clinical attention because of its multiple drug resistance. [6] [7] [4]In vitro, more than 90% of C. auris isolates are resistant to fluconazole [8] [9] and a range of 3–73% of C. auris isolates are resistant to voriconazole, [9] [10] while other triazoles (posaconazole, itraconazole, and isavuconazole) display better activity.
Candida hypersensitivity is a pseudoscientific syndrome promoted by William G. Crook, M.D. [1] It is spuriously claimed that chronic yeast infections are responsible for many common disorders and non-specific symptoms including fatigue, weight gain, constipation, dizziness, muscle and joint pain, asthma, and others.
Some subcutaneous fungal infections can invade into deeper structures, resulting in systemic disease. [3] Candida albicans can live in people without producing symptoms, and is able to cause both mild candidiasis in healthy people and severe invasive candidiasis in those who cannot fight infection themselves. [3] [7]
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