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There is evidence of risk when used during pregnancy but no evidence of harm with a single dose during breastfeeding. [17] [18] Midazolam was patented in 1974 and came into medical use in 1982. [19] It is on the World Health Organization's List of Essential Medicines. [20] Midazolam is available as a generic medication. [17]
Holly B. Shulman is an American statistician in the Division of Reproductive Health of the Centers for Disease Control and Prevention (CDC), a developer of the Pregnancy Risk Assessment Monitoring System for the CDC, [1] and the former president of the Caucus for Women in Statistics. [2]
The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. It does not include any risks conferred by pharmaceutical agents or their metabolites in breast milk. Every drug has specific information listed in its product literature.
An induced coma – also known as a medically induced coma (MIC), barbiturate-induced coma, or drug-induced coma – is a temporary coma (a deep state of unconsciousness) brought on by a controlled dose of an anesthetic drug, often a barbiturate such as pentobarbital or thiopental.
Polydrug use involving benzodiazepines and alcohol can result in an increased risk of blackouts, risk-taking behaviours, seizures, and overdose. [229] Dependence and tolerance, often coupled with dosage escalation, to benzodiazepines can develop rapidly among people who misuse drugs; withdrawal syndrome may appear after as little as three weeks ...
Fertility awareness methods may be used to avoid pregnancy, to achieve pregnancy, or as a way to monitor gynecological health. Methods of identifying infertile days have been known since antiquity, but scientific knowledge gained during the past century has increased the number, variety, and especially accuracy of methods.
Drugs during pregnancy and lactation: handbook of prescription drugs and comparative risk assessment. Elsevier. ISBN 978-0-444-50763-1. Schaefer C, Peters PW, Miller RK, eds. (2011). Drugs during pregnancy and lactation: treatment options and risk assessment (2nd ed.). Elsevier. ISBN 978-0-08-054977-4.