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An autophagosome is a spherical structure with double layer membranes. [2] It is the key structure in macroautophagy , the intracellular degradation system for cytoplasmic contents (e.g., abnormal intracellular proteins , excess or damaged organelles , invading microorganisms).
Autosomal traits are associated with a single gene on an autosome (non-sex chromosome)—they are called "dominant" because a single copy—inherited from either parent—is enough to cause this trait to appear. This often means that one of the parents must also have the same trait, unless it has arisen due to an unlikely new mutation.
22241 Ensembl ENSG00000177169 ENSMUSG00000029512 UniProt O75385 O70405 RefSeq (mRNA) NM_003565 NM_009469 NM_001347394 RefSeq (protein) NP_003556 NP_001334323 NP_033495 Location (UCSC) Chr 12: 131.89 – 131.92 Mb Chr 5: 110.93 – 110.96 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene. Unc-51 ...
ATG may be part of the protein name (such as ATG7) or part of the gene name (such as ATG7), [53] although all ATG proteins and genes do not follow this pattern (such as ULK1). [ 52 ] To give specific examples, the UKL1 enzyme (kinase complex) induces autophagosome biogenesis, and ATG13 ( Autophagy-related protein 13 ) is required for phagosome ...
The Atg1 gene lies on chromosome VII of S. cerevisiae. The encoded protein with a mass of 101.7 kDa has a length of 897 amino acids and includes a protein serine/threonin kinase domain of 302 amino acids at its N-terminus. At the C-terminus, there is a 7 amino acid long region that is required for Cvt trafficking.
A graphical representation of the typical human karyotype The human mitochondrial DNA. Human genetic variation is the genetic differences in and among populations.There may be multiple variants of any given gene in the human population (), a situation called polymorphism.
Pseudoplesiomorphy – is a trait that cannot be identified as neither a plesiomorphy nor an apomorphy that is a reversal. [18] Reversal – is a loss of derived trait present in ancestor and the reestablishment of a plesiomorphic trait. Convergence – independent evolution of a similar trait in two or more taxa. Hemiplasy [19] [20]
Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene. [5]ATG13 is an autophagy factor required for phagosome formation. . ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 comp