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In molecular biology, endonucleases are enzymes that cleave the phosphodiester bond within a polynucleotide chain (namely DNA or RNA).Some, such as deoxyribonuclease I, cut DNA relatively nonspecifically (with regard to sequence), while many, typically called restriction endonucleases or restriction enzymes, cleave only at very specific nucleotide sequences.
IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.
Depiction of the restriction enzyme (endonuclease) HindIII cleaving a double-stranded DNA molecule at a valid restriction site (5'–A|AGCTT–3').. In biochemistry, a nuclease (also archaically known as nucleodepolymerase or polynucleotidase) is an enzyme capable of cleaving the phosphodiester bonds that link nucleotides together to form nucleic acids.
Molecular and Cellular Biochemistry is a peer-reviewed scientific journal covering research in cellular biology and biochemistry. It was a successor to the journal Enzymologia and was established in 1973 to make "it possible to extend the potentialities of the periodical".
Indexed by ISI Journal of Biological Inorganic Chemistry received an impact factor of 2.538 as reported in the 2014 Journal Citation Reports by Thomson Reuters, ranking it 157 out of 289 journals in the category Biochemistry & Molecular Biology [2] and ranking it 9th out of 44 journals in the category Chemistry, Inorganic & Nuclear. [3]
More than 3,600 restriction endonucleases are known which represent over 250 different specificities. [7] Over 3,000 of these have been studied in detail, and more than 800 of these are available commercially. [8] These enzymes are routinely used for DNA modification in laboratories, and they are a vital tool in molecular cloning. [9] [10] [11]
Biochemical Genetics is a bimonthly peer-reviewed scientific journal covering molecular biology as it relates to genetics. It was established in 1967 and is published by Springer Science+Business Media. The editor-in-chief is Luís Filipe Dias e Silva (University of the Azores).
Molecular and Cellular Biology is a biweekly peer-reviewed scientific journal covering all aspects of molecular and cellular biology. It is published by the American Society for Microbiology and the editor-in-chief is Peter Tontonoz (University of California, Los Angeles). It was established in 1981. The h-index (1981-2021) is 338.