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Therefore, removal of the spleen runs the risk of overwhelming post-splenectomy infection, a medical emergency and rapidly fatal disease caused by the inability of the body's immune system to properly fight infection following splenectomy or asplenia. [1] Common indications for splenectomy include trauma, tumors, splenomegaly or for ...
An overwhelming post-splenectomy infection (OPSI) is a rare but rapidly fatal infection occurring in individuals following removal (or permanent dysfunction) of the spleen. The infections are typically characterized by either meningitis or sepsis , and are caused by encapsulated organisms including Streptococcus pneumoniae . [ 3 ]
Splenic artery embolization is a minimally invasive procedure and, where successful, avoids splenectomy. If an individual's spleen is enlarged, as is frequent in mononucleosis , most physicians will advise against activities (such as contact sports ) where injury to the abdomen could be catastrophic.
Splenomegaly is an enlargement of the spleen. [1] The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen.Splenomegaly is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the ...
Acquired asplenia occurs for several reasons: . Following splenectomy due to splenic rupture from trauma or because of tumor; After splenectomy with the goal of interfering with splenic function, as a treatment for diseases (e.g. idiopathic thrombocytopenic purpura, thalassemia, spherocytosis), in which the spleen's usual activity exacerbates the disease
Blunt splenic trauma most often occurs in automobile accident victims, in which it is a leading cause of internal bleeding. However, any type of major impact directed to the spleen may cause splenic trauma. This can happen in bicycling accidents, when the handlebar is forced into the left subcostal margin, and into the spleen.
As Rodriguez explains, most people with severe sickle cell disease — meaning they have pain crises between one to three times a year — end up needing to undergo a replacement surgery at some ...
Splenic infarct seen on CT Healed splenic infarct. Several factors may increase the tendency for clot formation, such as specific infections (such as infectious mononucleosis, [9] [dubious – discuss] [better source needed] cytomegalovirus infection, [10] malaria, [11] or babesiosis [12]), inherited clotting disorders (thrombophilia, such as Factor V Leiden, antiphospholipid syndrome ...