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Symptoms of postperfusion syndrome are subtle and include defects associated with attention, concentration, short-term memory, fine motor function, and speed of mental and motor responses. [1] Studies have shown a high incidence of neurocognitive deficit soon after surgery, but the deficits are often transient with no permanent neurological ...
The inability to break down glycogen within the lysosomes of cells leads to progressive muscle weakness throughout the body and affects various body tissues, particularly in the heart, skeletal muscles, liver and the nervous system. GSD-II and Danon disease are the only glycogen storage diseases characterised by a defect in lysosomal metabolism.
Hydrolases secreted into the blood stream cause little problem as they are inactivate at the near neutral pH of blood (7.4). [citation needed] It can be associated with N-acetylglucosamine-1-phosphate transferase (GNPTA). [6] In a case report, I-cell disease was complicated by severe dilative cardiomyopathy (DCM). [7]
It was the standard of care until the early 2000s, but was sidelined afterwards because patients frequently experienced renewed episodes of SCLS, and because these drugs were poorly tolerated due to their unpleasant side effects. [5] [13] [14]
The signs and symptoms of hypovolemia are primarily due to the consequences of decreased circulating volume and a subsequent reduction in the amount of blood reaching the tissues of the body. [9] In order to properly perform their functions, tissues require the oxygen transported in the blood. [10]
Apoptosis is the programmed cell death of superfluous or potentially harmful cells in the body. It is an energy-dependent process mediated by proteolytic enzymes called caspases, which trigger cell death through the cleaving of specific proteins in the cytoplasm and nucleus. [13] The dying cells shrink and condense into apoptotic bodies.
However, as the condition worsens, the symptoms can become more severe. [2] These symptoms include low urine output, nausea, vomiting, and loss of appetite. Some patients experience mental symptoms like confusion and may feel fatigued. Symptoms like fever, chills, irregular heartbeat, and quick/shallow breathing are also common.
Sick cell syndrome is a medical condition characterised by reduced functioning of the cellular Na+/K+ pump, [1] which is responsible for maintaining the internal ion homeostasis. The clinical result is a rise in blood K+ level and drop of blood Na+ levels