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The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel disease Biological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [ 1 ]
In humans, oral immunoglobulins may improve function in the gastrointestinal (GI) tract. [6] Conditions like HIV-enteropathy, IBS-D (irritable bowel syndrome with diarrhea), SIBO (small intestine bacterial overgrowth), recurrent C. difficile infection-associated diarrhea and post-infectious IBS-D often limit or impair the body's ability to absorb and digest select nutrients including water. [5]
Ulcerative colitis (UC) is one of the two types of inflammatory bowel disease (IBD), with the other type being Crohn's disease. [1] It is a long-term condition that results in inflammation and ulcers of the colon and rectum. [1] [7] The primary symptoms of active disease are abdominal pain and diarrhea mixed with blood (hematochezia). [1]
They have included bacterial blood infections, fever, SIRS-like syndrome, exacerbation of inflammatory bowel disease in people who also had that condition, and mild GI distress which generally resolve themselves soon after the procedure, including flatulence, diarrhea, irregular bowel movements, abdominal distension/bloating, abdominal pain ...
Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, with Crohn's disease and ulcerative colitis (UC) being the principal types. [3] Crohn's disease affects the small intestine and large intestine, as well as the mouth, esophagus, stomach and the anus, whereas UC primarily affects the colon ...
Inflammatory Bowel Diseases is a monthly peer-reviewed medical journal covering all aspects of inflammatory bowel disease. It was established in 1995 and is published by Oxford University Press. [1] It is the official journal of the Crohn's & Colitis Foundation. The editor-in-chief is Fabio Cominelli (Case Western Reserve University). [2]
[22] [23] Inflammatory bowel disease resulted in 47,400 deaths in 2015, [24] and those with Crohn's disease have a slightly reduced life expectancy. [1] It tends to start in adolescence and young adulthood, though it can occur at any age. [25] [1] [3] [26] Males and females are equally affected. [3]
World Inflammatory Bowel Disease Day, also known as World IBD Day, is an annual event to raise awareness of Crohn's disease and ulcerative colitis, known collectively as inflammatory bowel disease. [1] The day is coordinated by the European Federation of Crohn's and Ulcerative Colitis Associations (EFCCA).