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Hypergonadotropic hypogonadism (HH), also known as primary or peripheral/gonadal hypogonadism or primary gonadal failure, is a condition which is characterized by hypogonadism which is due to an impaired response of the gonads to the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and in turn a lack of sex steroid production. [1]
The Collaborative Perinatal Project (abbreviated CPP), also known as the National Collaborative Perinatal Project (or NCPP), was a multisite prospective cohort study designed to identify the effects of complications during either pregnancy or the perinatal period on birth and child outcomes, especially neurological disorders such as cerebral palsy. [1]
FHA can have long and short term consequences in a patient's reproductive development and fertility. Anovulation and amenorrhea is the characteristic feature of FHA. [3] If hypoestrogenism and impaired HPO axis occurs during puberty, primary amenorrhea occurs. [4]
Exposure to stress during the process of pregnancy affects fetal brain development and predisposes offspring to the development of a multitude of mental disorders. [17] Many studies have found that there is an association between ADHD and lessened functioning within the prefrontal cortex (PFC).
Childbirth can occur during natural sleep, [26] and under excessively heavy sedation, including alcohol intoxication. [27] A diverse list of medical disorders have led to delivery during coma, including head injury, antepartum bleeding, severe hypotension and hypothermia. [28] Of these the commonest is eclampsia. [29]
Early puberty also puts girls at a higher risk for teasing or bullying, mental health disorders and short stature as adults. [ 19 ] [ 39 ] [ 56 ] Girls as young as 8 are increasingly starting to menstruate , develop breasts and grow pubic and underarm hair; these "biological milestones" typically occurred only at 13 or older in the past.
Congenital iodine deficiency syndrome (CIDS), also called cretinism, [2] is a medical condition present at birth marked by impaired physical and mental development, due to insufficient thyroid hormone production (hypothyroidism) often caused by insufficient dietary iodine during pregnancy.
XY complete gonadal dysgenesis, also known as Swyer syndrome, is a type of defect hypogonadism in a person whose karyotype is 46,XY. Though they typically have normal vulvas, [1] the person has underdeveloped gonads, fibrous tissue termed "streak gonads", and if left untreated, will not experience puberty.