Search results
Results from the WOW.Com Content Network
Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. [5]
Pulmonary embolism (blood clots that have moved to the lung arteries) is usually treated with heparin generally followed by warfarin. If pulmonary embolism causes severe instability due to high pressure on the heart ("massive PE") and leads to low blood pressure, recombinant tPA is recommended. [22] [23] [24]
These recombinant forms of tPA have been shown to have a longer half-life in the blood and greater resistance to inhibition, resulting in an increased capacity to treat thrombolytic diseases. [11] Urokinase is similarly used in the medical field, specifically for the treatment of pulmonary embolism. [12]
Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in ...
The pulmonary embolism rule-out criteria (PERC) helps assess people in whom pulmonary embolism is suspected, but unlikely. Unlike the Wells score and Geneva score , which are clinical prediction rules intended to risk stratify people with suspected PE, the PERC rule is designed to rule out the risk of PE in people when the physician has already ...
But the American Heart Association warns against taking daily low-dose aspirin without talking to your doctor first. "Too may low-risk patients were taking aspirin in the past, sometimes without ...
Streptokinase is a thrombolytic medication activating plasminogen by nonenzymatic mechanism. [1] As a medication it is used to break down clots in some cases of myocardial infarction (heart attack), pulmonary embolism, and arterial thromboembolism. [2]
"While it’s true it's difficult to meet the RDA daily dose of 75 to 90 milligrams of vitamin C by eating only meat, there are about 25 micrograms per gram of vitamin C in fresh, grass-fed beef ...