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The Montreal Cognitive Assessment (MoCA) is a widely used screening assessment for detecting cognitive impairment. [1] It was created in 1996 by Ziad Nasreddine in Montreal , Quebec . It was validated in the setting of mild cognitive impairment (MCI), and has subsequently been adopted in numerous other clinical settings.
Elmer Verner McCollum (March 3, 1879 – November 15, 1967) was an American biochemist known for his work on the influence of diet on health. [2] [3] McCollum is also remembered for starting the first rat colony in the United States to be used for nutrition research.
Vitamin C was discovered in 1912, isolated in 1928 and synthesized in 1933, making it the first vitamin to be synthesized. [172] Shortly thereafter Tadeus Reichstein succeeded in synthesizing the vitamin in bulk by what is now called the Reichstein process. [173] This made possible the inexpensive mass-production of vitamin C.
In 1971, Barry Pressman and Henry Burdick launched Nature Made, inspired by the belief that “there was a better alternative to long term health than prescription drugs.” [1] [2] The company joined the Council for Responsible Nutrition (CRN) in 1981. [2] Nature Made began operating as a brand of Pharmavite as of this date.
Vitamin C megadosage is a term describing the consumption or injection of vitamin C (ascorbic acid) in doses well beyond the current United States Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2,000 milligrams per day. [1]
In the 1930s and 1940s, some scientific and clinical evidence suggested that there might be beneficial uses of vitamins C, E, and niacin in large doses. Beginning in the 1930s in Canada , a megadose vitamin E therapy for cardiovascular and circulatory complaints was developed by Evan Shute and colleagues, named the "Shute protocol". [ 15 ]
Vitamin C and the Common Cold is a popular book by Linus Pauling, first published in 1970, on vitamin C, its interactions with common cold and the role of vitamin C megadosage in human health. [1] The book promoted the idea that taking large amounts of vitamin C could reduce the duration and severity of the common cold. A Nobel Prize-winning ...
In absolute terms, the difference was just 1.3 cancer diagnoses per 1000 years of life. The hazard ratio for cancer diagnosis was 0.92 with a 95% confidence interval spanning 0.86–0.998 (P = .04); this implies a benefit of between 14% and .2% over placebo in the confidence interval.