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Lipodystrophy can appear as a lump or small dent in the skin that forms when a person performs injections repeatedly in the same spot. These types of lipodystrophies are harmless and can be avoided by changing (rotating) the locations of injections. For those with diabetes, using purified insulins and new needles with each injection may also help.
Acanthosis nigricans. Acanthosis nigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin. [ 1] It is usually found in body folds, [ 2] such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead and other areas. [ 1]
Lipohypertrophy [1] is a lump under the skin caused by accumulation of extra fat at the site of many subcutaneous injections of insulin. It may be unsightly, mildly painful, and may change the timing or completeness of insulin action. It is a common, minor, chronic complication of diabetes mellitus . Typical injection site hypertrophy is ...
Rabson–Mendenhall syndrome is a rare autosomal recessive disorder characterized by severe insulin resistance. The disorder is caused by mutations in the insulin receptor gene. Symptoms include growth abnormalities of the head, face and nails, along with the development of acanthosis nigricans. Treatment involves controlling blood glucose ...
Insulin resistance ( IR) is a pathological condition in which cells either fail to respond normally to the hormone insulin or downregulate insulin receptors in response to hyperinsulinemia . Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood glucose (blood sugar).
An estimated 40% of adults in the U.S. between the ages of 18 and 44 have insulin resistance, which is when the body doesn’t respond the way it should to insulin, a hormone the pancreas makes ...
A lipoma is a benign tumor made of fat tissue. [ 1] They are generally soft to the touch, movable, and painless. [ 1] They usually occur just under the skin, but occasionally may be deeper. [ 1] Most are less than 5 cm (2.0 in) in size. [ 2] Common locations include upper back, shoulders, and abdomen. [ 4]
Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...