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Body surface area. In physiology and medicine, the body surface area ( BSA) is the measured or calculated surface area of a human body. For many clinical purposes, BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the ...
Clark's rule. Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [ 1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK ...
Allometry ( Ancient Greek ἄλλος állos "other", μέτρον métron "measurement") is the study of the relationship of body size to shape, [ 1] anatomy, physiology and behaviour, [ 2] first outlined by Otto Snell in 1892, [ 3] by D'Arcy Thompson in 1917 in On Growth and Form [ 4] and by Julian Huxley in 1932.
Absorption is the journey of a drug travelling from the site of administration to the site of action. [ 1 ][ 2 ] The drug travels by some route of administration ( oral, topical-dermal, etc.) in a chosen dosage form (e.g., tablets, capsules, or in solution ). [ 3 ] Absorption by some other routes, such as intravenous therapy, intramuscular ...
The surface area of an adult is about 20,900 square centimeters (3,240 sq in) and the surface area of a child of 6 years is about 9,000 square centimeters (1,400 sq in). These figures and figures for other body parts or portions can be found in the EPA (Environmental Protection Agency) Exposures Handbook 1996 [ 22 ] or estimated using other ...
When a whole body is irradiated uniformly only the radiation weighting factor W R is used, and the effective dose equals the whole body equivalent dose. But if the irradiation of a body is partial or non-uniform the tissue factor W T is used to calculate dose to each organ or tissue. These are then summed to obtain the effective dose.
Dosages above are given according to the body surface area dosing model. The number of cycles given depends upon the stage of the disease and how well the patient tolerates chemotherapy. Doses may be delayed because of neutropenia, thrombocytopenia, or other side effects. [citation needed]
The absolute bioavailability is the dose-corrected area under curve ( AUC) non-intravenous divided by AUC intravenous. The formula for calculating the absolute bioavailability, F, of a drug administered orally (po) is given below (where D is dose administered). Therefore, a drug given by the intravenous route will have an absolute ...