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Body surface area. In physiology and medicine, the body surface area ( BSA) is the measured or calculated surface area of a human body. For many clinical purposes, BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the ...
Clark's rule. Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [ 1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK ...
Absorption is the journey of a drug travelling from the site of administration to the site of action. [ 1 ][ 2 ] The drug travels by some route of administration ( oral, topical-dermal, etc.) in a chosen dosage form (e.g., tablets, capsules, or in solution ). [ 3 ] Absorption by some other routes, such as intravenous therapy, intramuscular ...
Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. [4] The standard method of determining chemotherapy dosage is based on calculated body surface area (BSA).
The absolute bioavailability is the dose-corrected area under curve ( AUC) non-intravenous divided by AUC intravenous. The formula for calculating the absolute bioavailability, F, of a drug administered orally (po) is given below (where D is dose administered). Therefore, a drug given by the intravenous route will have an absolute ...
When a whole body is irradiated uniformly only the radiation weighting factor W R is used, and the effective dose equals the whole body equivalent dose. But if the irradiation of a body is partial or non-uniform the tissue factor W T is used to calculate dose to each organ or tissue. These are then summed to obtain the effective dose.
In the field of pharmacokinetics, the area under the curve ( AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry [ 1] ). In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is ...
Total body surface area. Total body surface area ( TBSA) is an assessment of injury to or disease of the skin, such as burns or psoriasis . In adults, the Wallace rule of nines can be used to determine the total percentage of area burned for each major section of the body. [ 1]