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Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]
[30] [31] In August 2014, the FDA approved apixaban for the additional indication of the treatment of recurring deep vein thrombosis and pulmonary embolism. [30] [32] During its development the drug was known as BMS-562247-01. [33] By late 2019, sales of the product by BMS accounted for thirty percent of their quarterly revenue. [34]
Synthesis of apixaban, as published by Pinto, et al. in 2007. [30] The notable key step is a (3+2)cycloaddition of the p-methoxyphenylchlorohydrazon derivate and the p-iodophenyl-morpholin-dihydropyridin derivate in the first reaction.
send or dispense, e.g. number of tablets provided Can be confused with m,. misce, context-dependent mane: mane: in the morning max. maximum maximum mcg microgram: recommended replacement for "μg" which may be confused with "mg" mdi metered dose inhaler m.d.u. more dicto utendus: to be used as directed mEq milliequivalent mg milligram
The NOC is a system to evaluate the effects of nursing care as a part of the nursing process. The NOC contains 330 outcomes, and each with a label, a definition, and a set of indicators and measures to determine achievement of the nursing outcome and are included The terminology is an American Nurses' Association -recognized terminology, is ...
The Nursing Interventions Classification (NIC) is a care classification system which describes the activities that nurses perform as a part of the planning phase of the nursing process associated with the creation of a nursing care plan.
Concomitant use of these and edoxaban may require 30 mg doses of edoxaban (instead of 60 mg). The efficacy of edoxaban may decrease when it is used with strong P-gp inducers such as phenytoin, carbamazepine, phenobarbital or St. John's Wort. If these medications are used with edoxaban, caution is advised. [12]
The common side effects of this combination are those of its individual drugs. For instance, the use of inhaled corticosteroids is associated with oral candidiasis, commonly known as yeast infection or thrush.