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An HPV infection is caused by the human papillomavirus, a DNA virus from the papillomavirus family. [8] [9] Over 200 types have been described. [10] An individual can become infected with more than one type of HPV, [11] and the disease is only known to affect humans.
Human papillomavirus (HPV)-associated oropharyngeal cancer awareness and prevention is a vital concept from a public and community health perspective. HPV is the sexually transmitted virus that is known to be the cause of genital warts. There are currently more than 100 different strains of HPV, half of which can cause genital infections. [1]
Papillomaviridae is a family of non-enveloped DNA viruses whose members are known as papillomaviruses. [1] Several hundred species of papillomaviruses, traditionally referred to as "types", [2] have been identified infecting all carefully inspected mammals, [2] but also other vertebrates such as birds, snakes, turtles and fish.
There are about 130 known types of human papillomaviruses. [9] HPV infects the squamous epithelium, usually of the skin or genitals, but each HPV type is typically only able to infect a few specific areas of the body. Many HPV types can produce a benign growth, often called a "wart" or "papilloma", in the area they infect. [10]
Squamous cell papilloma of the mouth or throat is generally diagnosed in people between the ages of 30 and 50, [1] and is normally found on the inside of the cheek, on the tongue, or inside of lips. Oral papillomas are usually painless, and not treated unless they interfere with eating or are causing pain. [ 1 ]
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It is caused by the human papilloma virus types 13 and 32. [3] It exhibits surface cells with vacuolated cytoplasm around irregular, pyknotic nuclei and occasional cells with mitosis-like changes within otherwise mature and well-differentiated epithelium. A distinguishing histologic feature is elongated rete ridges with mitosoid bodies.
A virus that can cause cancer is called an oncovirus or tumor virus. These include the human papillomavirus, which is associated with cervical carcinoma and nasopharyngeal carcinoma; Epstein-Barr virus, which is associated with a variety of Epstein-Barr virus-associated lymphoproliferative lymphomas; Kaposi's sarcoma herpesvirus, which is ...