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Nonsteroidal anti-inflammatory drugs (NSAIDs) alleviate pain by counteracting the cyclooxygenase (COX) enzyme. [1] On its own, COX enzyme synthesizes prostaglandins, creating inflammation. In whole, the NSAIDs prevent the prostaglandins from ever being synthesized, reducing or eliminating the inflammation and resulting pain. [citation needed]
Climber's finger is one of the most common climbing injuries within the sport of rock climbing, accounting for about 30% of finger injuries seen in climbers. [1] It is an overuse injury that usually manifests in a swollen middle or ring finger due to a damaged flexor tendon pulley , normally the A2 or A4 pulley.
NSAIDs reduce kidney blood flow and thereby decrease the efficacy of diuretics, and inhibit the elimination of lithium and methotrexate. [113] NSAIDs cause decreased ability to form blood clots, which can increase the risk of bleeding when combined with other drugs that also decrease blood clotting, such as warfarin. [113]
Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms.
Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom). A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes ...
A broken finger or finger fracture is a common type of bone fracture, affecting a finger. [1] Symptoms may include pain, swelling, tenderness, bruising, deformity and reduced ability to move the finger. [2] Although most finger fractures are easy to treat, failing to deal with a fracture appropriately may result in long-term pain and disability ...
Prostaglandin inhibitors are drugs that inhibit the synthesis of prostaglandin in human body. [1] There are various types of prostaglandins responsible for different physiological reactions such as maintaining the blood flow in stomach and kidney, regulating the contraction of involuntary muscles and blood vessels, and act as a mediator of inflammation and pain.
The next joint, moving closer to the hand, is the proximal interphalangeal (PIP) joint. The thumb differs by only having two bones and one interphalangeal joint. [10] The injured finger may be examined to determine where the pain is worst. [3] If the finger is sprained or dislocated, pain will be worse at the joint rather than the bone. [3]