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Dulaglutide, sold under the brand name Trulicity among others, [8] is a medication used for the treatment of type 2 diabetes in combination with diet and exercise. [9] [10] It is also approved in the United States for the reduction of major adverse cardiovascular events in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors.
The FDA has not approved GLP-1 agonists for type 1 diabetes, but they can be used off-label in addition to insulin to help type 1 diabetes patients improve their body weight and glucose control. [ 8 ]
Victoza is FDA-approved to treat type 2 diabetes but is also sometimes prescribed off-label for weight loss. Saxenda is FDA-approved for weight management in people with obesity. 3.
Drugs used in diabetes treat types of diabetes mellitus by decreasing glucose levels in the blood.With the exception of insulin, most GLP-1 receptor agonists (liraglutide, exenatide, and others), and pramlintide, all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic agents.
Insulin resistance, or low insulin sensitivity, happens when cells throughout the body don’t respond properly to the hormone insulin, especially cells in muscles, fat and the liver.
Another GLP-1 drug, Trulicity, which is also used to treat type 2 diabetes, was its third-best-selling drug, but saw its sales fall 31% to $1.25 billion as patients shifted to its newer GLP-1 ...
Alogliptin (FDA approved 2013 as Nesina/ Vipidia, marketed by Takeda Pharmaceutical Company) Trelagliptin (approved for use in Japan as Zafatek/ Wedica in 2015) Omarigliptin (MK-3102) (approved as Marizev in Japan in 2015, [ 12 ] developed by Merck & Co. ; research showed that omarigliptin can be used as once-weekly treatment and generally well ...
Sotagliflozin (Inpefa) is a dual SGLT1/SGLT2 inhibitor approved by the US Food and Drug Administration (FDA) in May 2023, to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure or type 2 diabetes, chronic kidney disease, and other cardiovascular risk factors.
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