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Dulaglutide, sold under the brand name Trulicity among others, [8] is a medication used for the treatment of type 2 diabetes in combination with diet and exercise. [9] [10] It is also approved in the United States for the reduction of major adverse cardiovascular events in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors.
A large study of more than 2 million people evaluated GLP-1 agonists' benefits and risks. The study showed that GLP-1 agonists reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders, cardiometabolic disorders, infectious illnesses, and several respiratory conditions. [5]
GLP-1 agonists are a class of medications that mimic the action of the hormone GLP-1 (glucagon-like peptide-1), which is involved in insulin production and appetite regulation. “GLP-1 stands for ...
Victoza is FDA-approved to treat type 2 diabetes but is also sometimes prescribed off-label for weight loss. Saxenda is FDA-approved for weight management in people with obesity. 3.
Alogliptin (FDA approved 2013 as Nesina/ Vipidia, marketed by Takeda Pharmaceutical Company) Trelagliptin (approved for use in Japan as Zafatek/ Wedica in 2015) Omarigliptin (MK-3102) (approved as Marizev in Japan in 2015, [ 12 ] developed by Merck & Co. ; research showed that omarigliptin can be used as once-weekly treatment and generally well ...
Another GLP-1 drug, Trulicity, which is also used to treat type 2 diabetes, was its third-best-selling drug, but saw its sales fall 31% to $1.25 billion as patients shifted to its newer GLP-1 ...
As of 2020, 23 unique antihyperglycemic drug combinations were approved by the FDA. [1] The first triple combination of oral anti-diabetics was approved in 2019, consisting of metformin, saxagliptin, and dapagliflozin. Another triple combination approval for metformin, linagliptin, and empagliflozin followed in 2020. [1]
The comments come after the FDA's staff on Wednesday flagged the risk of low blood sugar in type 1 diabetes patients, who are more insulin-dependent, and the lack of clinical data to support Novo ...
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