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  2. Lisa Stamp - Wikipedia

    en.wikipedia.org/wiki/Lisa_Stamp

    Stamp, Lisa K., John L. O'donnell, Mei Zhang, Jill James, Christopher Frampton, Murray L. Barclay, and Peter T. Chapman. "Using allopurinol above the dose based on creatinine clearance is effective and safe in patients with chronic gout, including those with renal impairment." Arthritis & Rheumatism 63, no. 2 (2011): 412–421.

  3. Allopurinol - Wikipedia

    en.wikipedia.org/wiki/Allopurinol

    Allopurinol has been marketed in the United States since 19 August 1966, when it was first approved by FDA under the trade name Zyloprim. [40] Allopurinol was marketed at the time by Burroughs Wellcome. Allopurinol is a generic drug sold under a variety of brand names, including Allohexal, Allosig, Milurit, Alloril, Progout, Ürikoliz, Zyloprim ...

  4. Clearance (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Clearance_(pharmacology)

    In these cases, clearance is almost synonymous with renal clearance or renal plasma clearance. Each substance has a specific clearance that depends on how the substance is handled by the nephron. Clearance is a function of 1) glomerular filtration , 2) secretion from the peritubular capillaries to the nephron , and 3) reabsorption from the ...

  5. Elimination (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Elimination_(pharmacology)

    Clearance is therefore expressed as the plasma volume totally free of the drug per unit of time, and it is measured in units of volume per units of time. Clearance can be determined on an overall, organism level («systemic clearance») or at an organ level (hepatic clearance, renal clearance etc.). The equation that describes this concept is:

  6. CYP1A2 - Wikipedia

    en.wikipedia.org/wiki/CYP1A2

    Moderate inhibitor being one that causes at least a 2-fold increase in the plasma AUC values of sensitive substrates metabolized through CYP1A2, or 50-80% decrease in clearance thereof. [ 18 ] Weak inhibitor being one that causes at least a 1.25-fold but less than 2-fold increase in the plasma AUC values of sensitive substrates metabolized ...

  7. Quiet Florida neighborhood rocked after three found dead ...

    www.aol.com/quiet-florida-neighborhood-rocked...

    Mary’s divorce petition also states that Nathan is "ex-military and has high security clearance," according to the Miami Herald. "I don’t want the public to lose faith," Tony added at ...

  8. Oxipurinol - Wikipedia

    en.wikipedia.org/wiki/Oxipurinol

    Oxipurinol (INN, or oxypurinol USAN) is an inhibitor of xanthine oxidase. [1] It is an active metabolite of allopurinol and it is cleared renally. [2] In cases of renal disease, this metabolite will accumulate to toxic levels.

  9. Trump’s power grab could dissuade military leaders from ...

    www.aol.com/news/trump-power-grab-could-dissuade...

    An executive order issued by President Donald Trump this week that seems to give him huge power to interpret the law is raising concerns among legal experts that it could dissuade military ...