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In null-hypothesis significance testing, the p-value [note 1] is the probability of obtaining test results at least as extreme as the result actually observed, under the assumption that the null hypothesis is correct. [2] [3] A very small p-value means that such an extreme observed outcome would be very unlikely under the null hypothesis.
The p-value was introduced by Karl Pearson [6] in the Pearson's chi-squared test, where he defined P (original notation) as the probability that the statistic would be at or above a given level. This is a one-tailed definition, and the chi-squared distribution is asymmetric, only assuming positive or zero values, and has only one tail, the ...
In order to calculate the significance of the observed data, i.e. the total probability of observing data as extreme or more extreme if the null hypothesis is true, we have to calculate the values of p for both these tables, and add them together. This gives a one-tailed test, with p approximately 0
To determine whether a result is statistically significant, a researcher calculates a p-value, which is the probability of observing an effect of the same magnitude or more extreme given that the null hypothesis is true. [5] [12] The null hypothesis is rejected if the p-value is less than (or equal to) a predetermined level, .
A faster method of log P determination makes use of high-performance liquid chromatography. The log P of a solute can be determined by correlating its retention time with similar compounds with known log P values. [40] An advantage of this method is that it is fast (5–20 minutes per sample).
Data dredging (also known as data snooping or p-hacking) [1] [a] is the misuse of data analysis to find patterns in data that can be presented as statistically significant, thus dramatically increasing and understating the risk of false positives.
Under Fisher's method, two small p-values P 1 and P 2 combine to form a smaller p-value.The darkest boundary defines the region where the meta-analysis p-value is below 0.05.. For example, if both p-values are around 0.10, or if one is around 0.04 and one is around 0.25, the meta-analysis p-value is around 0
The p-value of the test statistic is computed either numerically or by looking it up in a table. If the p-value is small enough (usually p < 0.05 by convention), then the null hypothesis is rejected, and we conclude that the observed data does not follow the multinomial distribution.