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Cytopathology of pleomorphic adenoma . It can usually be diagnosed by its typical fibrillary stroma (mesenchyme). Stromal cell nuclei are small. Myoepithelial cells are usually the predominant cell type, and their nuclei can have various shapes but are usually more elongated than in epithelial cells.
[2] [3] Certain benign cell types may also exhibit pleomorphism, e.g. neuroendocrine cells, Arias-Stella reaction. A rare type of rhabdomyosarcoma that is found in adults is known as pleomorphic rhabdomyosarcoma. [4] Despite the prevalence of pleomorphism in human pathology, its role in disease progression is unclear.
Benign tumour of the submandibular gland, also known as pleomorphic adenoma, presented as a painless neck mass in a 40-year-old man. At the left of the image is the white tumour with its characteristic cartilaginous cut surface. To the right is the normally lobated submandibular salivary gland. Warthin's tumor; Myoepithelioma; Basal cell ...
In approximately 75% of cases ca ex PAs arise in a pleomorphic adenoma that is apparent when the tumour is excised. [2] In the other approximately 25% of cases the individual had a pleomorphic adenoma excised previously and the diagnosis is made based on (1) the presence of a carcinoma, and (2) the history of a pleomorphic adenoma at that location.
Cytology of squamous metaplasia of the cervix, with typical features. Pap stain. Pap stain. Endometrial adenocarcinoma (carcinoma at left in image) with squamous differentiation evidenced as necrotic “ghost cells” of keratinocytes at right in image, leaving pink keratin as well as clear spaces at the prior locations of the cell nuclei.
An salivary gland oncocytoma (also known as an oxyphilic adenoma) is a well-circumscribed, benign neoplastic growth comprising about one percent of all salivary gland tumors. The histopathology is marked by sheets of large, swollen polyhedral epithelial oncocytes, which are granular acidophilic parotid cells with centrally located nuclei.
Rosacea. What it looks like: Rosacea causes redness and thick skin on the face, usually clustered in the center.Easy flushing, a stinging sensation, and small, pus-filled pimples are other common ...
Pleomorphic lipomas, like spindle-cell lipomas, occur for the most part on the backs and necks of elderly men and are characterized by floret giant cells with overlapping nuclei. [7]: 625 Spindle-cell lipomas are asymptomatic, slow-growing, subcutaneous tumors that have a predilection for the posterior back, neck, and shoulders of older men.