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5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), also known as O-methylbufotenin or mebufotenin (INN Tooltip International Nonproprietary Name), is a naturally occurring psychedelic of the tryptamine family. [5] [1] [4] [2] It is found in a wide variety of plant species, and is also secreted by the glands of at least one toad species, the Colorado ...
[1] [2] Several existing psychoplastogens have been identified and their therapeutic effects demonstrated; several are presently at various stages of development as medications including ketamine, MDMA, scopolamine, and the serotonergic psychedelics, including LSD, psilocin (the active metabolite of psilocybin), DMT, and 5-MeO-DMT.
5-Methyltryptamine (5-MeT, 5-Me-T) is a non-selective serotonin receptor agonist and serotonin releasing agent of the tryptamine family that has been used in scientific research. [ 1 ] [ 2 ] It is related to other 5- substituted tryptamines such as serotonin (5-hydroxytryptamine; 5-HT) and 5-methoxytryptamine (5-MeO-T).
5-MeO-DMT is a potent and fast-acting psychedelic, which is naturally produced by the Sonoran Desert toad as well as some species of plants. Its short duration –from 20 minutes to one hour– is ...
[1] [2] It is the 6-methoxy derivative of the serotonergic psychedelic N,N-dimethyltryptamine (DMT) and is a positional isomer of the serotonergic psychedelic 5-MeO-DMT. [3] Similarly to analogues like DMT and 5-MeO-DMT, 6-MeO-DMT acts as a serotonin 5-HT 2A receptor agonist as well as a non-selective agonist of many other serotonin receptors.
DMT molecule 5-MeO-DMT molecule Delosperma cooperi flower Delosperma lydenbergense flower Delosperma nubigenum. Many of the psychedelic plants contain dimethyltryptamine (DMT), or other tryptamines, which are either snorted (Virola, Yopo snuffs), vaporized, or drunk with MAOIs ().
5-Methoxy-7,N,N-trimethyltryptamine (5-MeO-7,N,N-TMT, 5-MeO-7-TMT), is a tryptamine derivative which acts as a partial agonist at the 5-HT 2 serotonin receptors, with an EC 50 of 63.9 nM and an efficacy of 66.2% at 5-HT 2A (vs 5-HT), and weaker activity at 5-HT 2B and 5-HT 2C.
α,N,O-TMS, or α,N-dimethyl-5-methoxy tryptamine, is a lesser-known psychedelic drug. Its abbreviated nomenclature is derived from its structure, as it is α, N , O -tri methyl serotonin . α, N , O -TMS was first synthesized by Alexander Shulgin .