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Folate and vitamin B 12 deficiency anemia usually presents with high RDW and high MCV. Mixed-deficiency (iron + B 12 or folate) anemia usually presents with high RDW and variable MCV. Recent hemorrhages typically present with high RDW and normal MCV. A false high RDW reading can occur if EDTA anticoagulated blood is used instead of citrated blood.
The MCV can be conceptualized as the total volume of a group of cells divided by the number of cells. For a real world sized example, imagine you had 10 small jellybeans with a combined volume of 10 μL. The mean volume of a jellybean in this group would be 10 μL / 10 jellybeans = 1 μL / jellybean. A similar calculation works for MCV.
The Mentzer index, described in 1973 by William C. Mentzer, [1] is the MCV divided by the RBC count. It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia trait. [2] [3] The index is calculated from the results of a complete blood count.
Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red blood cell (RBC) volume, yielding clues about morphology. [ citation needed ] Erythropoietic precursor indices
Mean corpuscular volume (MCV) Male: 76, [23] 82 [15] 100, [23] 102 [15] fL: Cells are larger in neonates, though smaller in other children. Female: 78 [15] 101 [15] fL Red blood cell distribution width (RDW) 11.5 [15] 14.5 [15] % Mean cell hemoglobin (MCH) 0.39 [14] 0.54 [14] fmol/cell: 25, [14] 27 [5] [23] 32, [23] 33, [5] 35 [14] pg/cell Mean ...
Anisocytosis is a medical term meaning that a patient's red blood cells are of unequal size. This is commonly found in anemia and other blood conditions. False diagnostic flagging may be triggered on a complete blood count by an elevated WBC count, agglutinated RBCs, RBC fragments, giant platelets or platelet clumps due to anisocytosis.
RDW, or rdw, may refer to: RDW (Dienst Wegverkeer), the organization that administers vehicle registration and driving licences in the Netherlands; Red blood cell distribution width, a parameter reported in blood tests; Reading West railway station (National Rail code), Berkshire, UK; Red Wing station (Amtrak code), Minnesota, US
The normal mean corpuscular volume (abbreviated to MCV on full blood count results, and also known as mean cell volume) is approximately 80–100 fL. When the MCV is <80 fL, the red cells are described as microcytic and when >100 fL, macrocytic (the latter occurs in macrocytic anemia). The MCV is the average red blood cell size.