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A free nerve ending (FNE) or bare nerve ending, is an unspecialized, afferent nerve fiber sending its signal to a sensory neuron. Afferent in this case means bringing information from the body's periphery toward the brain. They function as cutaneous nociceptors and are essentially used by vertebrates to detect noxious stimuli that often result ...
Meckel nerve endings are most numerous beneath the ridges of the fingertips which make up fingerprints, and less so in the palms and forearm. [citation needed] They can be found at a depth of 900 μm in human fingertips. [4] In hairy skin, Merkel nerve endings are clustered into specialized epithelial structures called "touch domes" or "hair ...
A nociceptor (from Latin nocere 'to harm or hurt'; lit. ' pain receptor ' ) is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals [ 1 ] [ 2 ] [ 3 ] to the spinal cord and the brain.
Tactile corpuscles are encapsulated myelinated nerve endings, [3] surrounded by Schwann cells. [3] The encapsulation consists of flattened supportive cells arranged as horizontal lamellae surrounded by a connective tissue capsule. The corpuscle is 30–140 μm in length and 40–60 μm in diameter.
With the advent of the electron microscope in the early 1950s, nerve endings were found to contain a large number of electron-lucent (transparent to electrons) vesicles. [27] [28] The term synaptic vesicle was first introduced by De Robertis and Bennett in 1954. [29]
At the papilla's core, a geometric constellation of nerve fibres with free endings is embedded symmetrically in a column of epithelial cells. Eimer saw two to three single nerve fibres, rising straight in the middle of the column and ending in the fifth layer under the stratum corneum that forms the hard top of the epidermis.
The vanilloid receptor (VR-1, TRPV1) is a receptor that is found on the free nerve endings of both C and Aδ fibers that responds to elevated levels of heat (>43 °C) and the chemical capsaicin. [10] Capsaicin activates C fibers by opening a ligand -gated ion channel and causing an action potential to occur. [ 10 ]
In physiology, nociception (/ˌnəʊsɪˈsɛpʃ(ə)n/), also nocioception; from Latin nocere 'to harm/hurt') is the sensory nervous system's process of encoding noxious stimuli. It deals with a series of events and processes required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize ...