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Phenethylamine is a potent agonist of the mouse, rat, and human trace amine-associated receptor 1 (TAAR1). [43] [2] β-PEA is also an odorant binding TAAR4 in mice thought to mediate predator avoidance. [44] Similarly to the case of amphetamine, phenethylamine shows enhanced locomotor stimulation, a psychostimulant-like effect, in TAAR1 ...
β-Methylphenethylamine (β-Me-PEA, BMPEA, or 1-amino-2-phenylpropane) is an organic compound of the phenethylamine class, and a positional isomer of the drug amphetamine, with which it shares some properties. In particular, both amphetamine and β-methylphenethylamine are human TAAR1 agonists. [2] In appearance, it is a colorless or yellowish ...
In contrast to phenethylamines and amphetamines generally, most psychedelic phenethylamines are not monoamine releasing agents. [ 145 ] [ 146 ] Examples of psychedelic phenethylamines and amphetamines include mescaline , the 2C drugs like 2C-B , 2C-D , 2C-E , and 2C-I , the DOx drugs like DOB , DOI , and DOM , certain MDxx drugs like MDA and ...
Substituted amphetamines are a chemical class of stimulants, entactogens, hallucinogens, and other drugs. They feature a phenethylamine core with a methyl group attached to the alpha carbon resulting in amphetamine, along with additional substitutions.
This shows phenethylamine in blue with its substitution points marked. Amphetamine and its substituted derivatives contain a CH 3 group at the alpha-position (R α). This shows amphetamine with its substitution points marked, excluding the N-position at the NH 2 group which is unmarked.
α-Propylphenethylamine (APPEA or α-Pr-PEA), also known as 1-phenyl-2-aminopentane, is a stimulant drug of the phenethylamine and amphetamine families. [1] [2] It is the analogue of the β-phenethylamine (PEA) derivatives amphetamine (α-methylphenethylamine; "AMPEA") and phenylisobutylamine (α-ethylphenethylamine; AEPEA) in which the α-alkyl chain has been further lengthened to be a propyl ...
2-Furylethylamine (2-FEA or FEA) is a drug of the arylalkylamine family related to the substituted phenethylamines such as β-phenethylamine (PEA) and amphetamine. [1] It is known to have similar pressor effects as amphetamine and strong constricting effects on the uterus in animals. [1] [2] [3] The psychoactive effects of FEA in humans are ...
Amphetamine [note 2] (contracted from alpha-methylphenethylamine) is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity; it is also used to treat binge eating disorder in the form of its inactive prodrug lisdexamfetamine.