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Phenethylamine is a potent agonist of the mouse, rat, and human trace amine-associated receptor 1 (TAAR1). [43] [2] β-PEA is also an odorant binding TAAR4 in mice thought to mediate predator avoidance. [44] Similarly to the case of amphetamine, phenethylamine shows enhanced locomotor stimulation, a psychostimulant-like effect, in TAAR1 ...
Amphetamine was discovered as a chemical in 1887 by Lazăr Edeleanu, and then as a drug in the late 1920s. It exists as two enantiomers: [note 3] levoamphetamine and dextroamphetamine. Amphetamine properly refers to a specific chemical, the racemic free base, which is equal parts of the two enantiomers in their pure amine forms. The term is ...
β-Methylphenethylamine (β-Me-PEA, BMPEA, or 1-amino-2-phenylpropane) is an organic compound of the phenethylamine class, and a positional isomer of the drug amphetamine, with which it shares some properties. In particular, both amphetamine and β-methylphenethylamine are human TAAR1 agonists. [2] In appearance, it is a colorless or yellowish ...
This shows phenethylamine in blue with its substitution points marked. Amphetamine and its substituted derivatives contain a CH 3 group at the alpha-position (R α). This shows amphetamine with its substitution points marked, excluding the N-position at the NH 2 group which is unmarked.
2-Furylethylamine (2-FEA or FEA) is a drug of the arylalkylamine family related to the substituted phenethylamines such as β-phenethylamine (PEA) and amphetamine. [1] It is known to have similar pressor effects as amphetamine and strong constricting effects on the uterus in animals. [1] [2] [3] The psychoactive effects of FEA in humans are ...
Phentermine, also known as α,α-dimethylphenethylamine or as α-methylamphetamine, is a substituted phenethylamine and amphetamine. [51] [52] [53] It is the derivative of amphetamine in which a second methyl group is present at the alpha carbon.
Wellbutrin vs Adderall: Differences and Similarities Anxiety and depression are two common mental conditions — it’s estimated that about 40 million adults deal with anxiety and an estimated 21 ...
2,5-Dimethoxy-4-cyanoamphetamine (DOCN) is a serotonergic drug of the phenethylamine, amphetamine, and DOx families. [1] [2] [3] It is a DOx derivative with a cyano group (–C≡N) at the 4 position of the molecule. [1] [2] [3] The drug shows much lower affinities for the serotonin 5-HT 2 receptors than other DOx drugs.