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  2. Targeted therapy of lung cancer - Wikipedia

    en.wikipedia.org/.../Targeted_therapy_of_lung_cancer

    Approximately 98% of lung cancers are carcinoma, a term describing malignancies derived from transformed cells exhibiting characteristics of epithelium. About 2% of all lung cancers are non-carcinoma (mainly sarcoma, tumors of hematopoietic origin, or germ cell tumors. [5] These forms of lung cancer are usually treated differently from carcinomas.

  3. ADAM17 - Wikipedia

    en.wikipedia.org/wiki/ADAM17

    Radiotherapy can induce a dose-dependent increase of furin-mediated cleavage of the ADAM17 proform to active ADAM17, which results in enhanced ADAM17 activity in vitro and in vivo. It was also shown that radiotherapy activates ADAM17 in non-small cell lung cancer, which results in shedding of multiple survival factors, growth factor pathway ...

  4. ADAM (protein) - Wikipedia

    en.wikipedia.org/wiki/ADAM_(protein)

    The ADAM11 gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [13] ADAM12: ADAM12, a metalloprotease that binds insulin growth factor binding protein-3 (IGFBP-3), appears to be an effective early Down syndrome ...

  5. ALK inhibitor - Wikipedia

    en.wikipedia.org/wiki/ALK_inhibitor

    ALK inhibitors are anti-cancer drugs that act on tumours with variations of anaplastic lymphoma kinase (ALK) such as an EML4-ALK translocation. [1] They fall under the category of tyrosine kinase inhibitors , which work by inhibiting proteins involved in the abnormal growth of tumour cells.

  6. Treatment of lung cancer - Wikipedia

    en.wikipedia.org/wiki/Treatment_of_lung_cancer

    Chemotherapy for NSCLC usually includes combination of two drugs (chemotherapy doublet), with one of the agents is cisplatin or carboplatin. In 2002, Schiller at al. published in the New England Journal of Medicine, a study that compared four chemotherapy regimens for advanced NSCLC, cisplatin and paclitaxel, cisplatin and gemcitabine, cisplatin and docetaxel, and carboplatin and paclitaxel. [14]

  7. TAPI-1 - Wikipedia

    en.wikipedia.org/wiki/TAPI-1

    TAPI-1 (TNF-alpha protease inhibitor I) is a structural analog of TAPI-0 with similar but more stable validness [clarification needed] in vitro for the matrix metalloproteinases (MMPs) and TNF- alpha converting enzyme [1] which blocks shedding of several cell surface proteins such as IL-6 and p60 TNF receptor.

  8. Small-cell carcinoma - Wikipedia

    en.wikipedia.org/wiki/Small-cell_carcinoma

    Small-cell lung carcinoma (SCLC) has long been divided into two clinicopathological stages, termed limited stage (LS) and extensive stage (ES). [8] The stage is generally determined by the presence or absence of metastases, whether or not the tumor appears limited to the thorax, and whether or not the entire tumor burden within the chest can feasibly be encompassed within a single radiotherapy ...

  9. Mayo Clinic Cancer Center - Wikipedia

    en.wikipedia.org/wiki/Mayo_Clinic_Cancer_Center

    The Mayo Clinic Cancer Center is one of the oldest NCI-designated cancer centers in the United States, having first been designated in 1973. [3] The main location of the Mayo Clinic is in Rochester, MN. Campuses in Arizona and Florida opened later and became part of the Mayo Clinic Cancer Center in 2003. [4] [5]