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The original antigenic sin: When the body first encounters an infection it produces effective antibodies against its dominant antigens and thus eliminates the infection. But when it encounters the same infection, at a later evolved stage, with a new dominant antigen, with the original antigen now being recessive, the immune system will still produce the former antibodies against this old "now ...
Original antigenic sin; Vaccine adverse event; Other ways in which antibodies can (unusually) make an infection worse instead of better Blocking antibody, which can be either good or bad, depending on circumstances; Hook effect, most relevant to in vitro tests but known to have some in vivo relevances
original antigenic sin. Also called antigenic imprinting and the Hoskins effect. The tendency of the human body's immune system to preferentially utilize immunological memory of a previous infection when a second, slightly different version of the pathogen (e.g. a virus or bacterium) is encountered in subsequent infections. The success of ...
This doctrine is known as the original antigenic sin. [21] This phenomenon comes into play particularly in immune responses against influenza , dengue and HIV viruses. [ 25 ] This limitation, however, is not imposed by the phenomenon of polyclonal response, but rather, against it by an immune response that is biased in favor of experienced ...
An illustration that shows how antigens induce the immune system response by interacting with an antibody that matches the molecular structure of an antigen. In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody or T-cell receptor. [1]
One model to explain this process is known as antibody-dependent enhancement (ADE), which allows for increased uptake and virion replication during a secondary infection with a different strain. Through an immunological phenomenon, known as original antigenic sin , the immune system is not able to adequately respond to the stronger infection ...
Original antigenic sin, descriptive diagram. en:Original antigenic sin refers to the propensity of the body's immune system to preferentially utilize immunological memory based on a previous infection when a second slightly different version of that foreign entity is encountered.
In wild birds, within-subtype antigenic variation appears to be limited but has been observed in poultry. [1] [11] Antigenic shift is a sudden, drastic change in an influenza virus' antigen, usually HA. During antigenic shift, antigenically different strains that infect the same cell can reassort genome segments with each other, producing ...