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Human betaherpesvirus 5, also called human cytomegalovirus (HCMV,HHV-5), [2] is a species of virus in the genus Cytomegalovirus, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. It is also commonly called CMV. [3]
Cidofovir (CDV) does not require initial phosphorylation for its antiviral action. Further phosphorylation to the triphosphate form of GCV and CDV is performed by cellular kinases. The nucleoside-triphosphate-analogues compete with the cellular nucleotide triphosphates at the viral polymerase pUL54 and are incorporated into the viral DNA.
Therefore, the presence of IgM in the blood of the host is used to test for acute infection, whereas IgG indicates an infection sometime in the past. [8] Both types of antibodies are measured when tests for immunity are carried out. [9] Antibody testing has become widely available.
The 11 species in this genus include human betaherpesvirus 5 (HCMV, human cytomegalovirus, HHV-5), which is the species that infects humans. Diseases associated with HHV-5 include mononucleosis and pneumonia , [ 4 ] [ 5 ] and congenital CMV in infants can lead to deafness and ambulatory problems.
Congenital cytomegalovirus (cCMV) is cytomegalovirus (CMV) infection in a newborn baby. [1] Most have no symptoms. [1] Some affected babies are small. [1] Other signs and symptoms include a rash, jaundice, hepatomegaly, retinitis, and seizures. [1] [2] It may lead to loss of hearing or vision, developmental disability, or a small head. [1]
Human cytomegalovirus (HCMV, HHV-5) "seems to have a large impact on immune parameters in later life and may contribute to increased morbidity and eventual mortality." [ 5 ] Human herpesvirus 6A (HHV-6A) has been described as more neurovirulent, [ 6 ] and as such is more frequently found in patients with neuroinflammatory diseases such as ...
From January 2008 to December 2012, if you bought shares in companies when Ruben M. Escobedo joined the board, and sold them when he left, you would have a -51.4 percent return on your investment, compared to a -2.8 percent return from the S&P 500.
During maturation of HHV-6 virions, human cell membranes are used to form viral lipid envelopes (as is characteristic of all enveloped viruses). During this process HHV-6 utilizes lipid rafts , which are membranous microdomains enriched by cholesterol , sphingolipids , and glycosylphosphatidylinositol -anchored proteins. [ 25 ]