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Phage therapy, viral phage therapy, or phagotherapy is the therapeutic use of bacteriophages for the treatment of pathogenic bacterial infections. [1] [2] [3] This therapeutic approach emerged at the beginning of the 20th century but was progressively replaced by the use of antibiotics in most parts of the world after the Second World War.
Phage therapy has been used for years in MRSA in eastern countries, and studies are ongoing in western countries. [146] [147] Host-directed therapeutics, including host kinase inhibitors, as well as antimicrobial peptides are under study as adjunctive or alternative treatment for MRSA. [148] [149] [150]
Mayo Clinic Florida is a comprehensive medical center belonging to the Mayo Clinic in Jacksonville, Florida. It is one of three Mayo campuses along with Phoenix/Scottsdale, Arizona and Rochester, Minnesota .
Another promising avenue is the integration of phage therapy, which has shown successive results in functional therapies. Phages, viruses that infect microbes including fungi, exhibit potent antimicrobial effects against various resistant fungal strains, demonstrating remarkable specificity and efficacy. [20]
Mycobacteriophage Bxb1 Structure [1]. A mycobacteriophage is a member of a group of bacteriophages known to have mycobacteria as host bacterial species. While originally isolated from the bacterial species Mycobacterium smegmatis and Mycobacterium tuberculosis, [2] the causative agent of tuberculosis, more than 4,200 mycobacteriophage species have since been isolated from various environmental ...
Robert "Chip" T. Schooley (born November 10, 1949) is an American infectious disease physician, who is the Vice Chair of Academic Affairs, Senior Director of International Initiatives, and Co-Director at the Center for Innovative Phage Applications and Therapeutics (IPATH), at the University of California San Diego School of Medicine.
The 'Nuts and Bolts' of Phage Therapy. a special issue of the journal, Current Pharmaceutical Biotechnology, consisting of six articles on phage therapy, plus an editorial. Carnazza, S., Guglielmino, S. eds. 2010. Phage Display As a Tool for Synthetic Biology. Nova Science Publishers, Hauppauge, New York. ISBN 978-1-60876-987-2, Google Books
Structural model at atomic resolution of bacteriophage T4 [1] The structure of a typical myovirus bacteriophage Anatomy and infection cycle of bacteriophage T4.. A bacteriophage (/ b æ k ˈ t ɪər i oʊ f eɪ dʒ /), also known informally as a phage (/ ˈ f eɪ dʒ /), is a virus that infects and replicates within bacteria and archaea.