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Cycloastragenol is a triterpenoid isolated from various legume species in the genus Astragalus that is purported to have telomerase activation activity. A preliminary in vitro study on human CD4 and CD8 T cells found that cycloastragenol may moderately increase telomerase activity and inhibit the onset of cellular senescence.
Longevity medicine is a set of preventive healthcare practices that rely on biomarkers of aging, such as aging clocks, to keep the patient's biological and psychological age as near to peak performance as feasible throughout life. [1] [2] Biogerontology and precision medicine are some of the related fields. [1]
Possible senolytic agents are under preliminary research, including some which are in early-stage human trials. [6] [7] [clarification needed] The majority of candidate senolytic compounds are repurposed anti-cancer molecules, such as the chemotherapeutic drug dasatinib and the experimental small molecule navitoclax.
An anti-aging therapy led to an extension of life by 25% in a new animal study. The treatment significantly decreased cancer-related deaths and reduced various diseases associated with fibrosis ...
Aducanumab, sold under the brand name Aduhelm, is a monoclonal antibody designed to treat Alzheimer's disease. It is a monoclonal antibody that targets aggregated forms (plaque) of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. [10] It was developed by Biogen and Eisai. [11] Aducanumab is given via intravenous infusion. [5] Aducanumab was ...
But some SASP components are anti-inflammatory. [11] Senescence and SASP can also occur in post-mitotic cells, notably neurons. [12] The SASP in senescent neurons can vary according to cell type, the initiator of senescence, and the stage of senescence. [12] An online SASP Atlas serves as a guide to the various types of SASP. [8]
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The term was coined by Lane, Ingram, Roth of the National Institute on Aging in a seminal 1998 paper in the Journal of Anti-Aging Medicine, the forerunner of Rejuvenation Research. [2] A number of genes and pathways have been shown to be involved with the actions of CR in model organisms and these represent attractive targets for drug discovery ...