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For many biologics (e.g., monoclonal antibodies), injection site reactions are the most common adverse effect of the drug, and have been reported to have an incidence rate of 0.5–40%. [ 2 ] In trials of subcutaneous administration of oligonucleotides , between 22 and 100% of subjects developed reactions depending on the oligonucleotide.
gabapentin – pain reliever; gentamicin/betamethasone valerate/clotrimazole – combination drug product used to treat ear disease in dogs; glycopyrrolate – emergency drug used for cardiac support; grapiprant - non-cyclooxygenase inhibiting nonsteroidal anti-inflammatory drug (NSAID)
A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture, steroids, and antibiotics. It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.
Signs of ear infection include shaking of the head, and scratching at or under the ear. Some animals may also paw the ear or try to rub it on other objects to relieve pain and discomfort. Ear infections often result in a darker red ear, dirt in the ear, or a general inflamed appearance. Chronic allergic otitis externa in a dog with atopic ...
Local anesthetic injections are given in specific areas of the mouth, rather than the whole body. Although several different medications are available, the most commonly used local anesthetic to prevent pain in the area around a tooth is lidocaine (also called xylocaine or lignocaine). Lidocaine's half-life in the body is about 1.5–2 hours. [2]
Skin: itching, depigmentation, rash, urticaria, edema, angioedema, bruising, inflammation of the vein at the injection site, irritation of the skin when applied topically; Blood: methemoglobinemia; Allergy; ADRs associated with the use of intravenous lidocaine are similar to the toxic effects of systemic exposure above.
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