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As early as the 1860s, with the work of Hermann Helmholtz in experimental psychology, the brain's ability to extract perceptual information from sensory data was modeled in terms of probabilistic estimation. [5] [6] The basic idea is that the nervous system needs to organize sensory data into an accurate internal model of the outside world.
Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of neuroscience which employs mathematics, computer science, theoretical analysis and abstractions of the brain to understand the principles that govern the development, structure, physiology and cognitive abilities of the nervous system.
In the field of computational neuroscience, brain simulation is the concept of creating a functioning computer model of a brain or part of a brain. [1] Brain simulation projects intend to contribute to a complete understanding of the brain, and eventually also assist the process of treating and diagnosing brain diseases .
This model was simplified with the FitzHugh–Nagumo model in 1962. [9] By 1981, the Morris–Lecar model had been developed for the barnacle muscle. These mathematical models proved useful and are still used by the field of biophysics today, but a late 20th century development propelled the dynamical study of neurons even further: computer ...
As early as 2006, researchers at Georgia Tech published a field programmable neural array. [13] This chip was the first in a line of increasingly complex arrays of floating gate transistors that allowed programmability of charge on the gates of MOSFETs to model the channel-ion characteristics of neurons in the brain and was one of the first cases of a silicon programmable array of neurons.
The Blue Brain Project was able to model these networks using algebraic topology. [13] In 2018, Blue Brain Project released its first digital 3D brain cell atlas [14] which, according to ScienceDaily, is like "going from hand-drawn maps to Google Earth", providing information about major cell types, numbers, and positions in 737 regions of the ...
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This model is the Integrate-and-Fire (IF) model that was mentioned in Section 2.3. Closely related to IF model is a model called Spike Response Model (SRM) (Gerstner, W. (1995) [15] Pages 738-758) that is dependent on impulse function response convoluted with the input stimulus signal. This forms a base for a large number of models developed ...