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Acetazolamide, sold under the trade name Diamox among others, is a medication used to treat glaucoma, epilepsy, acute mountain sickness, periodic paralysis, idiopathic intracranial hypertension (raised brain pressure of unclear cause), heart failure and to alkalinize urine.
Altitude acclimatization is the process of adjusting to decreasing oxygen levels at higher elevations, in order to avoid altitude sickness. [17] Once above approximately 3,000 metres (10,000 ft) – a pressure of 70 kilopascals (0.69 atm) – most climbers and high-altitude trekkers take the "climb-high, sleep-low" approach.
Acetazolamide is an inhibitor of carbonic anhydrase.It is used for glaucoma, epilepsy (rarely), idiopathic intracranial hypertension, and altitude sickness. For the reduction of intraocular pressure (IOP), acetazolamide inactivates carbonic anhydrase and interferes with the sodium pump, which decreases aqueous humor formation and thus lowers IOP.
The second day ascends over Dead Woman's pass- the highest point on the trail at 4,200 metres. This is the most dangerous point for altitude sickness, though little time is spent at this elevation and the trail descends again to 3,600 metres. From here, the trail only descends until arriving at Machu Picchu at 2,430 metres.
Machu Picchu [a] is a 15th-century Inca citadel located in the Eastern Cordillera of southern Peru on a mountain ridge at 2,430 meters (7,970 ft). [9] Often referred to as the "Lost City of the Incas", [10] it is the most familiar icon of the Inca Empire.
The Historic Sanctuary of Machu Picchu [2] is a protected area in Peru covering over 35,000 hectares. It includes the natural environment surrounding the Machu Picchu archaeological site, located in the rugged cloud forest of the Yungas on the eastern slope of the Peruvian Andes and along both banks of the Urubamba River, which flows northwest in this section.
Traveling on New Year’s Day, however, only saves you about 9% on airfare compared to other peak-period days, and then you have to deal with a hangover at altitude. Are airports crowded on holidays?
The process of acclimatization generally takes several days, but may be helped by drugs, such as Diamox. Acute mountain sickness (AMS) may develop into high altitude pulmonary edema (HAPE) or high altitude cerebral edema (HACE), both of which are life-threatening and require immediate transportation to a lower altitude. [13]
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