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The endothelium (pl.: endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. [1] The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
In addition to regulating the exit and entrance of blood, the blood–brain barrier also filters toxins that may cause inflammation, injury, and disease. [12] The overall microvasculature unit functions as a defense for the central nervous system. [11] Encompassed within the BBB are two types of blood vessels: endothelial and mural cells ...
The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood. [1]
The maturation of blood vessels in the brain is a critical process that occurs postnatally. [6] It involves the acquisition of key barrier and contractile properties essential for brain function. During the early postnatal phase, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) undergo significant molecular and functional changes.
Various cell types play a role in HR, including astrocytes, smooth muscle cells, endothelial cells of blood vessels, and pericytes. These cells control whether the vessels are constricted or dilated, which dictates the amount of oxygen and glucose that is able to reach the neuronal tissue. Brain blood vasculature as a function of blood flow.
Within the brain, the glial limiting membrane is an important constituent of the blood–brain barrier. Experiments using electron-dense markers have discovered that functional components of the blood–brain barrier are the endothelial cells that compose the vessel itself.
Cocoa contains a flavanol, epicatechin, that relaxes blood vessels’ endothelial cell layer, improving their function and addressing elevated blood pressure, which is a common reaction to stress.
The lymphatic endothelium refers to a specialized subset of endothelial cells located in the sinus systems of draining lymph nodes.Specifically, these endothelial cells line the branched sinus systems formed by afferent lymphatic vessels, forming a single-cell layer which functions in a variety of critical physiological processes.