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Induced pluripotent stem cell taken from blood cell and converted in retinal pigment epithelium. Stem cell therapy for macular degeneration is an emerging treatment approach aimed at restoring vision in individuals suffering from various forms of macular degeneration, particularly age-related macular degeneration (AMD). [1]
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
Retinal layers, from bottom to top: retinal pigment epithelium (RPE), photoreceptors (PR), horizontal cells (HC), bipolar cells (BC), amacrine cells (AC), ganglion cells (RGC), nerve fiber layer (RNFL). A retinal implant is a visual prosthesis for restoration of sight to patients
Retinal regeneration in zebrafish is mediated by Muller glia, which dedifferentiate into stem-like cells and proliferate into neural progenitor cells in response to retinal damage. While Muller glia division is responsible for the regeneration of the retina in all cases of retinal damage, the case of photoreceptor loss due to light damage is ...
Stem-cell therapy involves injecting cells with the potential to mature into differentiated and functioning retinal cells. This therapy has the potential stop disease progression and in the long term improve vision. To improve vision this technique will need to replicate the complex multi-layered and neurally anatomy of the retina.
Foundation-funded researchers are using stem cells derived from a variety of sources, including a person's own skin, to create healthy retinal cells that can potentially restore vision. Stem cell treatments hold great promise for people with advanced vision loss.
Other published developments include new surgical techniques for the treatment of retinal detachment, macular degeneration, glaucoma, lens surgery, new laser techniques, and stem cell therapy in the eye. Another scientific focus is the translational research on the new partial corneal transplantation (DMEK, Descemetmembranous Endothelial ...
Retinal detachment is a condition where the retina pulls away from the tissue underneath it. [1] [2] [3] It may start in a small area, but without quick treatment, it can spread across the entire retina, leading to serious vision loss and possibly blindness. [4] Retinal detachment is a medical emergency that requires surgery. [2] [3]