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Δ-8-tetrahydrocannabinol (delta-8-THC, [a] Δ 8-THC) is a psychoactive cannabinoid found in the cannabis plant. [1] It is an isomer of delta-9-tetrahydrocannabinol (delta-9-THC, Δ 9-THC), the compound commonly known as THC, with which it co-occurs in hemp; natural quantities of ∆ 8-THC found in hemp are low.
Cannabis is detectable by saliva testing. Just like blood testing, saliva testing detects the presence of parent drugs and not their inactive metabolites. This results in a shorter window of detection for cannabis by saliva testing. [23] Delta 9 THC is the parent compound.
11-Hydroxy-Δ-8-tetrahydrocannabinol (11-OH-Δ 8-THC, alternatively numbered as 7-OH-Δ 6-THC) is an active metabolite of Δ 8-THC, a psychoactive cannabinoid found in small amounts in cannabis. It is an isomer of 11-OH-Δ 9-THC, and is produced via the same metabolic pathway. It was the first cannabinoid metabolite discovered in 1970. [1]
8,11-Dihydroxytetrahydrocannabinol (8β,11-diOH-Δ 9-THC) is an active metabolite of THC, the main active component of cannabis.The 8β enantiomer retains psychoactive effects in animal studies with only slightly lower potency than THC, while the 8α enantiomer is much weaker.
Catalytic acid solution in 5 minutes in a microwave oven with a 40% THC (Δ9-THC) and 35% Δ-8-Tetrahydrocannabinol yield. [22] Adding protons until the CBD sterically-hindered alcohol functional group cyclises to the pyran ring of THC. [23] Lewis acids. [24] - a continuous rather than batch implementation with similar materials [8]
In an in vitro analysis by the University of Rhode Island on cannabinoids it was found that 11-OH-Δ 9-THC had the 3rd highest 3C-like protease inhibitor activity against COVID-19 out of all the cannabinoids tested within that study but not as high as the antiviral drug GC376 (56% for 11-OH-Δ 9-THC vs. 100% for GC376). [8]
In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance ...
According to the U.S. Food and Drug Administration (FDA), Delta-8 THC is “is a psychoactive substance found in the Cannabis sativa plant.” It is one of 100 substances that come naturally from ...
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