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[4] [5] Use is not recommended during pregnancy. [2] Xylometazoline is in the decongestant and alpha-adrenergic agonist families of medication. [5] [6] One study classified it with selectivity ratios in alpha 2 adrenergic receptors of 151 for a2A vs a2B, 4.5 a2A vs a2C, and 33.9 a2B vs a2C. Making it a highly selective a2A agonist. [7]
Cannabis use during pregnancy should be avoided. [80] There is no known safe dose of cannabis while pregnant and use of cannabis may lead to birth defects, pre-term birth, or low birth weight. [80] Tetrahydrocannabinol (THC), an active ingredient in cannabis, can both cross the placenta and accumulates in high concentrations in breast milk. [81]
Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. [5] This includes allergic rhinitis (hay fever) and hives. [5] It is also available in drug combinations such as loratadine/pseudoephedrine, in which it is combined with pseudoephedrine, a nasal decongestant. [5]
For children suffering from allergies, Reigart says saline nose drops or first generation antihistamines such as Benadryl can be beneficial for congestion. But oftentimes, you can skip the meds.
It is unclear if it is safe in pregnancy. [5] It appears safe in breastfeeding. [11] Greater care is recommended in those with heart problems. [12] It is an anticholinergic agent, [5] which does not have much effect on the brain. [13] Hyoscine butylbromide was patented in 1950, and approved for medical use in 1951. [14]
Phenylpropanolamine (PPA), sold under many brand names, is a sympathomimetic agent which is used as a decongestant and appetite suppressant. [ 9 ] [ 1 ] [ 10 ] [ 11 ] It was previously commonly used in prescription and over-the-counter cough and cold preparations .
Phenylephrine, sold under the brand names Neosynephrine and Sudafed PE among others, is a medication used as a decongestant for uncomplicated nasal congestion in the form of a nasal spray or oral tablet, [5] to dilate the pupil, to increase blood pressure given intravenously in cases of low blood pressure, and to relieve hemorrhoids as a suppository.
Propylhexedrine, sold under the brand name Benzedrex among others, is a nasal decongestant of the alkylamine family and related to the arylalkylamines. [1] Its main indications are relief of congestion due to colds, allergies, and allergic rhinitis. [2]