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Half maximal inhibitory concentration (IC 50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC 50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50%. [1]
Amisulpride is approved and used at low doses in the treatment of dysthymia and major depressive disorder. [10] [20] [11] [21] [22] [23] Whereas typical doses used in schizophrenia block postsynaptic dopamine D 2-like receptors and reduce dopaminergic neurotransmission, low doses of amisulpride preferentially block presynaptic dopamine D 2 and D 3 autoreceptors and thereby disinhibit dopamine ...
Common side effects include ... (50 mg/day , 75 mg/day, 100 ... However the activity of nitrofurantoin is also pH dependent and mean inhibitory concentration rises ...
Side effects of molindone include extrapyramidal symptoms and tardive ... (IC 50 Tooltip half-maximal inhibitory concentration = 84–140 ... (10 and 40 mg/kg) ...
Half maximal effective concentration (EC 50) is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time. [1] More simply, EC 50 can be defined as the concentration required to obtain a 50% [...] effect [2] and may be also written ...
Side effects of pargyline include orthostatic hypotension ... The dosage was 12.5 to 200 mg per day ... (IC 50 Tooltip half-maximal inhibitory concentration = 8.20 ...
The drug has an affinity (K i) of 0.087 to 0.5 nM for the serotonin 5-HT 2A receptor and 0.44 to 10 nM at the serotonin 5-HT 2C receptor, whereas its functional inhibition (IC 50 Tooltip half-maximal inhibitory concentration) values have been reported to be 1.9 nM at the serotonin 5-HT 2A receptor and 91 nM at the serotonin 5-HT 2C receptor.
In addition, a 4-(methylsulfonyl)phenyl or 4-sulfamoylphenyl is known to be necessary for COX-2 inhibition. For instance, replacing either of these entities with a –SO 2 NHCH 3 substituent diminishes COX-2 inhibitory activity as noted with a very high inhibitory concentration-50 (see structures 3 – 5). At the 3-position of the pyrazole, a ...