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PDE5 inhibitors increase blood flow to your privates, ... Viagra begins to work 30 to 60 minutes after taking it. ... This can result in higher-than-normal levels of sildenafil in your body, which ...
Some reports say that since Viagra can widen blood vessels, it can increase blood flow through the heart, permitting more oxygen to the lungs and improving oxygen supply to the rest of the body.
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Many of these pills work fairly quickly. Sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) typically start working within 30 to 60 minutes, while avanafil (Stendra) works within 15 ...
It requires sexual arousal to work, and does not by itself cause or increase sexual arousal. [8] It also results in dilation of the blood vessels in the lungs. [8] Pfizer originally discovered the medication in 1989 while looking for a treatment for angina. [11] It was approved for medical use in the United States and in the European Union in 1998.
Sildenafil (marketed as Viagra) was the first PDE5 inhibitor on the market. Originally created as a treatment for high blood pressure in 1989, it was found to have a secondary use as an effective PDE5 inhibitor, enabling men who use it to gain stronger erections after arousal. The FDA approved Viagra on March 27, 1998. [20]
Research has found that taking Viagra does not increase high blood pressure. Sildenafil, the active ingredient in Viagra, is actually used to treat a certain kind of high blood pressure in the lungs.
How Effective is Sildenafil 100mg? Sildenafil works well for most men with ED at any dosage, although the highest 100mg dosage produces improvements for a greater percentage of men than 50mg or 25mg.