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Retinol-binding protein 4 has been a drug target for eye diseases as RBP4 is the sole carrier for retinol, which is an essential nutrient for the visual cycle. Animal studies using RBP4-antagonists showed that lowering RBP4 can lead to reduction in the accumulation of lipofuscin that leads to vision loss in eye diseases like Stargardt's disease ...
Plasma retinol-binding protein, the retinol transport vehicle in serum. [13] CRBP I/II, cellular-binding proteins involved in transport of retinol and metabolites into retinyl esters for storage or into retinoic acid. [14] CRABPs, cellular retinoic acid–binding proteins capable of binding retinol and retinoic acid with high affinity.
5928 19646 Ensembl ENSG00000162521 ENSMUSG00000057236 UniProt Q09028 Q60972 RefSeq (mRNA) NM_005610 NM_001135255 NM_001135256 NM_009030 RefSeq (protein) NP_001128727 NP_001128728 NP_005601 NP_033056 Location (UCSC) Chr 1: 32.65 – 32.69 Mb Chr 4: 129.2 – 129.23 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a ...
They are known respiratory allergens of mice, cats, dogs, horses, and other animals. Examples of lipocalin proteins involved in immune system responses include alpha-1-microglobulin, alpha-1-acid glycoprotein, and C8gamma. Structural information for many immune system influencing lipocalin proteins is available, while their exact role in ...
5949 19661 Ensembl ENSG00000265203 ENSMUSG00000041534 UniProt P10745 P49194 RefSeq (mRNA) NM_002900 NM_015745 RefSeq (protein) NP_002891 NP_056560 Location (UCSC) Chr 10: 47.35 – 47.36 Mb Chr 14: 33.68 – 33.69 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinol-binding protein 3, interstitial (RBP3), also known as interphotoreceptor retinoid-binding protein (IRBP), is a ...
The protein is upregulated in times of vitamin A deficiency. If vitamin A status is in the normal range, SCARB1 is downregulated, reducing absorption. [ 6 ] Also downregulated is the enzyme beta-carotene 15,15'-dioxygenase (formerly known as beta- carotene 15,15'-monooxygenase) coded for by the BCMO1 gene, responsible for symmetrically cleaving ...
19659 Ensembl ENSG00000114115 ENSMUSG00000046402 UniProt P09455 Q00915 RefSeq (mRNA) NM_002899 NM_001130992 NM_001130993 NM_001365940 NM_011254 RefSeq (protein) NP_001124464 NP_001124465 NP_002890 NP_001352869 NP_035384 Location (UCSC) Chr 3: 139.52 – 139.54 Mb Chr 9: 98.31 – 98.33 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinol binding protein 1, cellular, also known as ...
Retinyl esters can be distinguished from retinol in serum and other tissues and quantified with the use of methods such as high-performance liquid chromatography. [ 21 ] Elevated amounts of retinyl ester (i.e., >10% of total circulating vitamin A) in the fasting state have been used as markers for chronic hypervitaminosis A in humans and ...
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