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Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate ...
CYP1A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
As sleep time decreased over time from the 1950s to 2000s from about 8.5 hours to 6.5 hours, there has been an increase in the prevalence of obesity from about 10% to about 23%. [2] Weight gain itself may also lead to a lack of sleep as obesity can negatively affect quality of sleep, as well as increase risk of sleeping disorders such as sleep ...
Spicy foods have great metabolism boosting benefits to help you drop a few pounds, but bringing the heat can lead to a restless night because it raises your core body temperature which can affect ...
Losing too much sleep can also impair coordination and motor skills, Shelby Harris, Psy.D., a clinical psychologist specializing in behavioral sleep medicine and director of sleep health at ...
Febuxostat, sold under the brand name Uloric among others, is a medication used long-term to treat gout due to high uric acid levels. [7] It is generally recommended only for people who cannot take allopurinol.
All of these are examples of circadian rhythm disorders, which are problems with the alignment between your sleep-wake cycle and your responsibilities for the day—like going to work or school ...
Allopurinol is taken orally, at a typical dose of 3–20 mg/kg per day. The dose is then adjusted to bring the uric acid level down into the normal range (<3 mg/dL). Most affected individuals can be treated with allopurinol all through life. [citation needed] No medication is effective in controlling the extrapyramidal motor features of the ...