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A bone scan or bone scintigraphy / s ɪ n ˈ t ɪ ɡ r ə f i / is a nuclear medicine imaging technique used to help diagnose and assess different bone diseases. These include cancer of the bone or metastasis , location of bone inflammation and fractures (that may not be visible in traditional X-ray images ), and bone infection (osteomyelitis).
where, is a convolution operator, C bone (t) is the bone tissue activity concentration of tracer (in units: MBq/ml) over a period of time t, C plasma (t) is the plasma concentration of tracer (in units: MBq/ml) over a period of time t, IRF(t) is equal to the sum of exponentials, β values are fixed between 0.0001 sec −1 and 0.1 sec −1 in ...
3-dimensional [18 F]FDG-PET image with 3D ROI generated by a threshold based algorithm.The blue dot in the MIP image bottom right marks the maximum SUV within the ROI.. The standardized uptake value (SUV) is a nuclear medicine term, used in positron emission tomography (PET) as well as in modern calibrated single photon emission tomography (SPECT) imaging for a semiquantitative analysis. [1]
Bone metastases on PET scan are usually multiple, irregularly distributed foci of increased tracer uptake without relationship to a single anatomic structure. [15] A PET scan can directly identify tumor cells with significant metabolic rate. However, it is a costly procedure and device availability may be limited. [15]
Planar X-ray reveals soft tissue swelling and may potentially show gas within necrotic muscle, Bone scan may show non specific uptake later in the course. CT shows muscle oedema with preserved tissue planes (non-contrast enhancing). MRI is the exam of choice and shows increased signal on T2 weighted images within areas of muscle oedema.
SPECT scans are significantly less expensive than PET scans, in part because they are able to use longer-lived and more easily obtained radioisotopes than PET. Because SPECT acquisition is very similar to planar gamma camera imaging, the same radiopharmaceuticals may be used. If a patient is examined in another type of nuclear medicine scan ...
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DPD scanning typically uses a gamma camera to obtain SPECT images, with an injection followed by an initial scan after 5 minutes, and a second scan after 3 hours. [3] Images are often scored using the "Perugini system" whereby: [4] [5] Grade 0 – no cardiac uptake and normal bone uptake; Grade 1 – cardiac uptake which is less intense than ...