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The smaller arteries are also constricted and this causes the colour of the nasal epithelium to be visibly paler after dosage. Xylometazoline is an imidazole derivative which is designed to mimic the molecular shape of adrenaline. It binds to α 1 and α 2 adrenergic receptors [11] in the nasal mucosa.
Oxymetazoline, sold under the brand name Afrin among others, is a topical decongestant and vasoconstrictor medication. It is available over-the-counter as a nasal spray to treat nasal congestion and nosebleeds, as eye drops to treat eye redness due to minor irritation, and (in the United States) as a prescription topical cream to treat persistent facial redness due to rosacea in adults.
Nasal sprays are used to deliver medications locally in the nasal cavities or systemically. They are used locally for conditions such as nasal congestion and allergic rhinitis . In some situations, the nasal delivery route is preferred for systemic therapy because it provides an agreeable alternative to injection or pills.
In a surprise to its makers, a nasal spray intended to be an alternative to the EpiPen was sent back by the FDA, the company announced.
Last week the FDA approved Neffy, an epinephrine nasal spray, for use in emergency allergic reactions for kids and adults. Retired allergist at the Northwest Asthma & Allergy Center Paul Williams ...
The U.S. health regulator has declined to approve a nasal spray that would have been the first needle-free emergency treatment for allergic reactions, a surprise decision that sent shares of its ...
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