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Vaginal estrogen is a form of estrogen that is delivered by intravaginal administration. Vaginally administered estrogens are thereby exerting their effects mainly in the nearby tissue, with more limited systemic effects compared to orally administered estrogens. [ 1 ]
It contains ethinylestradiol, an estrogen, and etonogestrel, a progestin. [4] It is used by insertion into the vagina. [3] Pregnancy occurs in about 0.3% of women with perfect use and 9% of women with typical use. [5] Common side effects include irregular vaginal bleeding, nausea, sore breasts, vaginitis, mood changes, and headache. [6]
• Vaginal dryness: Estrogen thickens the lining of the walls of the vagina, so when levels of the hormone drop, that vaginal tissue thins and becomes dry, leading to pain, soreness, or burning ...
Estradiol (E2) is a medication and naturally occurring steroid hormone. [11] [12] [13] It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women.
[186] [10] Vaginal estradiol can be used both as a systemic form of estradiol therapy, and at very low doses to selectively achieve a local vaginal effect without systemic effects, for instance in the treatment of menopausal symptoms such as vaginal atrophy and dryness. [10] [254] Vaginal estradiol is rapidly and almost completely absorbed. [72]
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