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Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 27 ]
Depakene is the trade name for the same drug prepared without sodium. Desyrel – an atypical antidepressant used to treat depression and insomnia; Desoxyn (methamphetamine hydrochloride) – used to treat attention deficit hyperactivity disorder and exogenous obesity
The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.
There are two types of insomnia: short-term insomnia and chronic insomnia. Short-Term Insomnia Short-term insomnia is when you have trouble sleeping for a period of days or weeks.
A new study reveals a shocking potential cause for insomnia.
High doses of many shorter-acting benzodiazepines may also cause anterograde amnesia and dissociation. [4] These properties make benzodiazepines useful in treating anxiety , panic disorder , insomnia , agitation , seizures , muscle spasms , alcohol withdrawal and as a premedication for medical or dental procedures. [ 5 ]
In fact, while magnesium and melatonin are commonly taken by people trying to get better shuteye, magnesium can cause gastrointestinal issues and melatonin is often sold in higher doses than what ...
The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...