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  2. Amyloid plaques - Wikipedia

    en.wikipedia.org/wiki/Amyloid_plaques

    The diagnosis of Alzheimer's disease typically requires a microscopic analysis of plaques and tangles in brain tissue, usually at autopsy. [40] However, Aβ plaques (along with cerebral Aβ-amyloid angiopathy ) can be detected in the brains of living subjects by preparing radiolabeled agents that bind selectively to Aβ deposits in the brain ...

  3. New test may detect Alzheimer's years before tau clumps ... - AOL

    www.aol.com/test-may-detect-alzheimers-years...

    Amyloid-beta: As Alzheimer’s disease develops, amyloid precursor proteins clump together to create amyloid-beta plaques, which eventually disrupt how brain cells work. Tau: In the healthy brain ...

  4. Biochemistry of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biochemistry_of_Alzheimer's...

    The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy : a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain . [ 1 ]

  5. Biomarkers of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biomarkers_of_Alzheimer's...

    Aβ42 is the initial and major component of amyloid plaque deposits. While the most prevalent hypothesis for mechanisms of Aβ-mediated neurotoxicity is structural damage to the synapse, various mechanisms such as oxidative stress, [ 6 ] altered calcium homeostasis, induction of apoptosis , structural damage, chronic inflammation and neuronal ...

  6. Study challenges current views about toxic plaque formation ...

    www.aol.com/study-challenges-current-views-toxic...

    New research is contradicting previously held views that only neurons secret beta-amyloid that forms toxic plaques, a marker of Alzheimer's disease in the brain. The study points to another ...

  7. New study challenges amyloid-beta theory on cause for ... - AOL

    www.aol.com/study-challenges-amyloid-beta-theory...

    A main theory behind the cause of Alzheimer’s disease is the build-up of the protein amyloid-beta in the brain. Researchers from the University of Cincinnati provide evidence suggesting it’s ...

  8. Amyloid beta - Wikipedia

    en.wikipedia.org/wiki/Amyloid_beta

    Amyloid beta (Aβ, Abeta or beta-amyloid) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. [2] The peptides derive from the amyloid-beta precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol ...

  9. Some people have Alzheimer’s without symptoms: What ... - AOL

    www.aol.com/lifestyle/people-alzheimer-without...

    “There are many people with pathological markers of Alzheimer’s disease without Alzheimer’s symptoms. Beta-amyloid, the pathological marker of Alzheimer’s disease, can start to accumulate ...

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